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Author

Adonicah Y. Cummings

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Review Open access Oct 2026

Caspase-1 and Inflammasome Signaling in Spinal Cord Injury: Mechanistic Insights and Translational Gaps

Caspase-1 is a central mediator of canonical inflammasome signaling and drives neuroinflammatory injury through interleukin-1β (IL-1β) and interleukin-18 (IL-18) maturation, gasdermin D (GSDMD)-mediated pyroptosis, and secondary inflammatory cascades. In spinal cord injury (SCI) and other neurologic disorders, experime...

Adonicah Y. Cummings, Adham M. Khalafallah, Bhavjeet S. Sanghera et al. · 0 citations

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