Review
Open access
Sep 2026
Engineering Polymeric Vectors for Nucleic Acid Delivery: Linking Molecular Architecture, Biological Function, and Computational Design
This review examines how molecular weight, polymer composition, cationic group chemistry and density, pKa, and polymer topology influence complexation efficiency with nucleic acid, polymer to nucleic acid ratio (N/P), polyplex stability, cellular uptake, endosomal escape, cytotoxicity, and transfection efficiency.
Joachim Emeka Arikibe, Anna Maria Mazzetta, Lisa Casagrande et al.
· Open Research Europe · 0 citations