Postprandial hyperglycemia is a well-established therapeutic target in diabetes mellitus, and the intestinal α-glucosidases maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) catalyze the terminal step of starch digestion. As approved inhibitors have limited uptake due to gastrointestinal adverse effects, there re...
L. Oliveira, João Bosco Ferreira de Souza, Dayara Soares Ruas et al.· Revista de Estudos Interdisc...· 0 citations
Six predicted candidate genes in Staphylococcus aureus may represent the main points of convergence between resistance mechanisms and biofilm formation, constituting priority targets for genomic association studies and for the development of new therapeutic strategies.
Agueda Maria de França Tavares, Eliane Macedo Sobrinho Santos, Renata Gabriela Chaves Ferreira et al.· Folia Microbiologica (Prague...· 0 citations
The findings support the potential of these flavonoids as selective, low-toxicity SQLE inhibitor candidates and reinforce the value of in silico screening in guiding future in vitro and in vivo validation of novel antifungal therapies derived from plant biodiversity.
L. Oliveira, Agueda Maria de França Tavares, Aderson Vasconcelos Santos et al.· Revista de Estudos Interdisc...· 0 citations
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