Author

Ahmadreza Mofayezi

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Preprint Aug 2026

A Conditional Structure-Aware Generative Transformer for Multi-Objective Design of m1{\Psi}-Modified RNA 5'UTRs

This work describes a conditional generative framework for 50-nt modified-RNA 5'UTR design that optionally conditions on ribosome load, GC content, minimum free energy, and target secondary structure and uses a Transformer-based generator followed by sequence ranking and local refinement.

Narges Zarnaghinaghsh, Ahmadreza Mofayezi, Byung-Jun Yoon · 0 citations