Author

Ahmed A. Mohamed

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Review Oct 2026

Caloric restriction mimetics rewire the AMPK-mTOR-ULK1 signaling nexus to restore autophagic proteostasis in the aging brain.

Brain aging is driven by progressive failure of neuronal proteostasis, culminating in the accumulation of toxic protein aggregates characteristic of Alzheimer's, Parkinson's, and Huntington's diseases. The AMPK-mTOR-autophagy signaling hub integrates cellular energy status with protein clearance machinery, making it a...

H. Al-Jehani, Hayder M. Al-kuraishy, Ahmed M. Abdelaziz et al. · Molecular and cellular neuro... · 0 citations

Review Sep 2026

Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP.

Berberine, a naturally occurring isoquinoline alkaloid found in several medicinal plants such as Berberis spp. and Coptis chinensis has long been used in traditional medicine. Recent evidence positions berberine as a pleiotropic modulator of multiple interconnected hallmarks of aging, making it a promising candidate fo...

S. M. Alanazi, Hayder M. Al-kuraishy, Ahmed M. Abdelaziz et al. · Fitoterapia · 0 citations

Review Sep 2026

Targeting the α7-nicotinic acetylcholine receptor in multiple sclerosis: Implications for immunomodulation and neuroprotection.

By integrating immunomodulatory and neuroprotective actions, α7-nAChR targeting represents a mechanistically compelling strategy for comprehensive disease modification in MS, although clinical translation remains contingent upon overcoming significant pharmacological and biomarker-related challenges.

A. Al-Dhahi, Hayder M. Al-kuraishy, Ahmed A. Mohamed et al. · Life Science · 0 citations