Ahmed El-Harairy

Computational design and evaluation of tacrine-based carbamate derivatives as acetylcholinesterase inhibitors

Alzheimer's disease is marked by a gradual decline in cognitive function accompanied by alterations in cholinergic signaling. Cholinergic function can be improved by targeting acetylcholinesterase (AChE). In this work, an in silico approach was applied to study a series of tacrine-based carbamate derivatives. 3D-QSAR m...