Synthesis, characterization, and evaluation of novel diphenylpyrazole-based hydrazine-1-carboximidamides as broad-spectrum antibacterial leads with antibiofilm and virulence-modulating activities
The emergence of multidrug-resistant bacterial pathogens and biofilm-associated infections highlights the urgent need for antibacterial agents with novel chemical architectures and complementary modes of action. In the present study, a new series of diphenylpyrazole-based hydrazine-1-carboximidamide derivatives (5a–i)...