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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Ahmed M. Abdelaziz

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4 papers indexed here

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Review Oct 2026

Caloric restriction mimetics rewire the AMPK-mTOR-ULK1 signaling nexus to restore autophagic proteostasis in the aging brain.

Brain aging is driven by progressive failure of neuronal proteostasis, culminating in the accumulation of toxic protein aggregates characteristic of Alzheimer's, Parkinson's, and Huntington's diseases. The AMPK-mTOR-autophagy signaling hub integrates cellular energy status with protein clearance machinery, making it a...

H. Al-Jehani, Hayder M. Al-kuraishy, Ahmed M. Abdelaziz et al. · 0 citations
Review Sep 2026

Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP.

Berberine, a naturally occurring isoquinoline alkaloid found in several medicinal plants such as Berberis spp. and Coptis chinensis has long been used in traditional medicine. Recent evidence positions berberine as a pleiotropic modulator of multiple interconnected hallmarks of aging, making it a promising candidate fo...

S. M. Alanazi, Hayder M. Al-kuraishy, Ahmed M. Abdelaziz et al. · 0 citations
Review Open access Oct 2026

The immunoproteasome in Alzheimer's disease: a dual regulator of tau pathology and microglial senescence.

Alzheimer's disease (AD) is characterized by progressive cognitive decline driven by the convergence of tauopathy, impaired proteostasis, and chronic neuroinflammation. Emerging evidence identifies the immunoproteasome (iP), particularly the β5i/LMP7 subunit, as a central regulator linking these pathological processes....

Mustafa M. Shokr, Ahmed M. Abdelaziz · 0 citations
Review Aug 2026

Immunopharmacological reprogramming of innate immune memory in Alzheimer's disease: From microglial priming to therapeutic resilience.

It is argued that the next generation of AD therapeutics must move beyond target suppression toward the functional reprogramming of brain innate immunity, and a biomarker-guided, patient-stratified framework is proposed that integrates multimodal immunopharmacology, combining NLRP3 inhibition, TREM2 agonism, metabolic...

Ahmed M. Abdelaziz, Reem M. Eladawy · 0 citations

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