Author

Ahmed Mohamed Farghly

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Open access Aug 2026

Buspirone attenuates cyclophosphamide-induced renal dysfunction in association with alterations in miR-205/EGLN2, Nrf2, and PERK/ATF4/CHOP signaling

Buspirone pretreatment mitigated CPA-induced renal dysfunction, accompanied by increased miR-205 expression, reduced EGLN2 expression, enhanced Nrf2-associated antioxidant defenses, and attenuation of ER stress, inflammation, and apoptosis, thereby preserving renal function and tissue integrity.

Ahmed M. El-Dessouki, A. Alrashidi, Mohammad I Jumaa et al. · Frontiers in Pharmacology · 0 citations