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It is thought that increasing the number of novel specific agonists and antagonists targeting TRPM8 gating would be useful therapeutic targets in manipulating molecular mechanisms of pain.
Oxidative stress, impairments of cellular ATP production and changes in membrane integrity of mitochondria are components of mitochondrial dysfunction and are cross borders of several neurodegenerative diseases. Sodium azide is a chemical agent targeting mitochondrial oxidative phosphorylation and widely used in experi...
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