Ahyoung Lee

SUMOylation modulates glucocorticoid-induced muscle toxicity in cell and mouse models.

Prolonged glucocorticoid (GC) exposure is a clinically relevant cause of skeletal muscle atrophy through activation of glucocorticoid receptor (GR)-dependent catabolic transcriptional programs, including those mediated by Krüppel-like factor 15 (KLF15). However, the post-translational regulatory mechanisms that modulat...