Ai-Min Song

Discovery of Highly Selective Noncovalent Macrocyclic Peptide Inhibitors Suppressing Both TMPRSS2 Protease Activity and Viral Receptor Function

MCPs are highlighted as promising, highly selective TMPRSS2-directed antiviral lead compounds that exhibited dual functionality by inhibiting both the enzymatic and receptor functions of TMPRSS2, as demonstrated by their blockade of the HKU1 coronavirus spike protein binding.