Open access
Sep 2026
Metabolic dysregulation linked to sickling tendency in sickle cell anemia independent of HbF.
Sickle cell disease (SCD) presents substantial interindividual clinical variability that remains only partially explained by genotype, fetal hemoglobin (HbF), and co-inherited alpha-thalassemia. We investigated whether endogenous metabolites modulate the sickling tendency, independently of HbF. We analyzed 368 steady-s...
S. van der Veen, A. Idrizovic, T. Sanavia et al.
· Blood Cells, Molecules & Dis... · 0 citations