Aideen E. Ryan

Cancer-associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma.

Although substantial advances have been made in cancer immunotherapy, the immunosuppressive tumour microenvironment (TME) continues to pose a significant obstacle to the achievement of sustained clinical responses. Cancer-associated fibroblasts (CAFs) are increasingly recognised as pivotal regulators in the TME. Their...