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Author

Aiko Turmo

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Open access Aug 2026

Structural and functional analysis of LarC, a CTP-dependent cyclometallase required for nickel-pincer nucleotide cofactor biosynthesis

Biosynthesis of the nickel-pincer mononucleotide metallocofactor requires a CTP-dependent nickel insertion reaction catalyzed by LarC, whose mechanism of C-Ni bond formation is not fully understood. Here, we report the first cryo–electron microscopy structures of full-length LarC from Moorella thermoacetica with and wi...

Robert Wolfe, Aiko Turmo, Samantha Velasquez-Rivertte et al. · 0 citations

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