Author

Aiwu Ke

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Open access Jul 2026

The PON1-NDUFA4 axis maintains mitochondrial respiratory fitness and drives lenvatinib tolerance in hepatocellular carcinoma.

These findings identify the PON1-NDUFA4 axis as a previously unrecognized metabolic vulnerability that sustains mitochondrial respiratory fitness and lenvatinib resistance in HCC.

Shi-Lin Lin, Yue Wang, Yi-Min Zheng et al. · Molecular Cancer Research · 0 citations