Ru(II)-catalyzed site-selective C5 acylmethylation/annulation of 2-arylquinolin-4(1H)-ones with sulfoxonium ylides via weak coordination.
A novel ruthenium(II)-catalyzed, oxo-directed C5-H acylmethylation of 2-arylquinolin-4(1H)-ones with sulfoxonium ylides has been developed. Weak carbonyl coordination overrides the competing nitrogen center, providing excellent C5 selectivity. The procedure shows excellent tolerance of functional groups, a broad substr...