Open access
Jul 2026
The m⁶A reader YTHDF2 regulates mRNA transport and axon outgrowth in developing neurons
It is found that the ablation of Mettl14 in postmitotic neurons leads to impaired axonal projection during corticogenesis, and the authors show that m6A RNA marks recruit YTHDF2-associated transport machinery that favors transport over degradation, localizing selected mRNAs to neurites to promote cortical axon projection.
Bonsang Koo, Ajeet Kumar, H. Hwang et al.
· Nature Communications · 0 citations