Author

Akanksha Arun

2 papers indexed here

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Open access Aug 2026

Morpheus-3D: Structural Diversity-Guided Detection and Localization of Protein Fold Switching

Proteins that reversibly adopt multiple stable folds challenge the classical sequence–structure paradigm, yet their discovery remains limited because fold switching is difficult to detect experimentally and current computational methods fail to resolve the underlying conformationally plastic regions. Here we present Mo...

Sreeharsh Kuniyil, Vijay Subramanian, Akanksha Arun et al. · bioRxiv · 0 citations

Open access Aug 2026

A programmable lipid-triggered allosteric site modulates LC3 LIR receptor binding activity

It is uncovered that membrane binding triggers a major conformational transition in LC3, exposing functional pockets that are occluded in its cytosolic form and can be engineered to precisely tune LC3-LIR interactions, offering a new strategy to regulate selective autophagy.

Deepanshi Gahlot, Jesu Castin, S. Mathur et al. · Nature Communications · 0 citations