Open access
Aug 2026
Persistent export bias of TDP-43 under native autoregulation links insoluble accumulation to nuclear dysfunction.
Nuclear depletion and cytoplasmic mislocalization of TDP-43 are central pathological features of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 protein levels are normally maintained by autoregulation through its native 3' untranslated region (3' UTR), but whether this feedback remains prot...
Genri Toyama, Shingo Koide, Takuma Yamagishi et al.
· Neurobiology of Disease · 0 citations