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Background: Spinal cord stimulation (SCS) is an established therapy for chronic neuropathic pain, yet a substantial minority of implanted patients do not obtain durable relief, and patient selection still relies largely on a subjective percutaneous stimulation trial. Objective neurophysiological and psychophysical biom...
Background and Objectives: Orthobiologic injectables—principally platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), cell-based therapies and, increasingly, extracellular vesicles—are widely used for chronic musculoskeletal (MSK) pain, yet their evidence base is inconsistent and guideline endorsement i...
Future progress in SCS will likely depend on artificial intelligence, remote monitoring, biomarker-guided programming, and integration with multidisciplinary chronic pain care.
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