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Alana Battad

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Open access Aug 2026

Glyoxalase 1 Regulates Methylglyoxal-Derived Nucleic Acid Adduct Burden

Increased metabolic stress associated with diabetes and cancer increases the level of reactive dicarbonyl molecules that covalently modify nucleic acids. Methylglyoxal (MG), one of the most abundant endogenous dicarbonyl electrophiles, reacts with guanine bases in DNA and RNA to form covalent adducts that compromise...

Alana Battad, Francisco Núñez, S. Lai et al. · Chemical Research in Toxicol... · 0 citations