Picolinamide-directed palladium(II)-catalyzed regioselective hydroacyloxylation of unactivated alkenes.
A method for the palladium(II)-catalyzed highly regioselective hydroacyloxylation of unactivated alkenes with carboxylic acids is described using a picolinamide directing group via a Wacker-type nucleopalladation pathway. This novel strategy paves the way for generating very useful β-amino alcohols and esters from simp...