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Author

Albel Singh

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Open access Sep 2026

An adenylyl cyclase switch reroutes carbon from growth to virulence lipids in Mycobacterium tuberculosis

Agonists of the adenylyl cyclase Rv1625c are a novel drug class that selectively inhibits Mtb growth in macrophages and cholesterol-rich conditions by an unknown mechanism and hijack an endogenous switch that reroutes carbon from biomass to virulence-lipid production.

S. C. Immanuel, Julie S. Do, E. Peterson et al. · 0 citations

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