Alden Filko

Regulatory time-kill sequencing maps antibiotic-specific transcriptional control of Escherichia coli persistence at genome scale

Bacterial persistence enables a phenotypically tolerant subpopulation to survive lethal antibiotic exposure, contributing to the recalcitrance of chronic infections and facilitating the evolution of heritable resistance. Despite its importance, a systems-level, quantitative understanding of how transcriptional regula...