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Findings indicate that individualized morphometric similarity networks capture a dimension of PD heterogeneity beyond conventional motor phenotypes and may provide a biologically informed framework for patient stratification.
It is demonstrated that the brain networks associated with RBD, depression and anxiety non-motor symptoms were largely overlapping, involved the attention networks and were spatially aligned with the noradrenergic system, suggesting that these symptoms may have shared neurobiological substrates.
Two biologically distinct PD subtypes are identified with divergent molecular architecture and systemic neurodegeneration beyond conventional motor phenotyping beyond conventional motor phenotyping.
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