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Author

Alec J. Hirsch

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2 papers indexed here

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Open access Aug 2026

Discovery of a 4′‐Azido Fleximer Nucleoside Analog With Broad‐Spectrum Antiviral Activity Against DENV, EBOV, and Other RNA Viruses

The ongoing emergence and reemergence of RNA viruses from multiple viral families highlights the urgent need for broad‐spectrum antiviral therapeutics. To address this issue, a series of 4′‐azido fleximer nucleoside analogs were synthesized and evaluated for broad‐spectrum antiviral activity against pathogens of epidem...

Kyle A. Davis, Ryan L. Slack, Thomas R. Foulkes et al. · 0 citations
Open access Sep 2026

Evaluation of a Zika virus-like particle-based vaccine in a highly penetrant non-human primate model of congenital infection

A highly pathogenic nonhuman primate pregnancy model is evaluated for its ability to assess vaccine-mediated protection using a Zika virus-like particle (VLP) vaccine as a test platform and results support a high risk of early pregnancy loss following African-lineage ZIKV-DAK 41524 infection in RM.

Hannah K. Jaeger, Jessica L. Smith, C. Labriola et al. · 0 citations

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