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Author

Alejandra Mondino

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2 papers indexed here

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Open access Sep 2026

SOD1:c.118G>A mutation in the Cimarrón Uruguayo dog: prevalence, drift dynamics, and structural effects

Abstract Canine degenerative myelopathy (DM) is associated with a missense mutation in the SOD1 gene (c.118G>A), which results in the E40K amino acid substitution and promotes protein aggregation mechanisms similar to those described in human amyotrophic lateral sclerosis. The present study estimated the frequency of t...

Rody Artigas, Carolina Menchaca, Eugenio Jara et al. · 0 citations
Sep 2026

Aging dogs exhibit heterogeneous cognitive decline trajectories: A longitudinal comparative model.

BackgroundBoth dogs and humans experience substantially variable cognitive decline with age. In humans, this ranges from healthy cognitive aging to early onset Alzheimer's disease. While different rates of cognitive decline have been described in purpose-bred beagles, few studies have examined longitudinal trajectories...

K. E. Simon, Wojciech K. Panek, Gilad Fefer et al. · 0 citations

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