Alejandro Cisterna García

Structure-Aware Contrastive Learning for Biomedical Embeddings: Bridging the Gap Between HPO and Clinical Literature

A new embedding adaptation procedure is defined whose fine-tuning approach is guided by a novel "Disease-Overlap" similarity measure, which prioritizes clinical co-occurrence of phenotypes over taxonomic distance, and optimizes the embedding space using AnglE Loss to mitigate gradient saturation.