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Author

Alejandro V. Villarino

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Open access Sep 2026

Impaired regulation by purinergic signaling axis contributes to CD8+ T cell dysregulation in STAT3 gain of function

It is found that in patients with STAT3 GOF, CD8+ T cells exist in an activated state and a dysregulated purinergic signaling axis plays a key role in CD8+ T cell dysregulation in STAT3 GOF and may have implications for other rare monogenic immune disorders and common inflammatory disorders.

Jose S. Campos Duran, Montana Knight, Samir U. Sayed et al. · 0 citations
Open access Jul 2026

A BACH2-STAT5 transcriptional module licenses a short intracellular C3 proteoform in activated CD4+ T cells 2308647

A BACH2—STAT5 transcriptional module is identified that is essential for C3 expression in activated CD4+ T cells and redirects C3 output toward a short, intracellular proteoform with noncanonical complement activity.

Jorge Trujillo, D. Chauss, Luopin Wang et al. · 0 citations

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