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Ales Varabyou

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Open access Sep 2026

Improving Metagenomics Classification with Kmask: Entropy-Based Masking of Low-Complexity Regions

Kmask, an entropy-based masking tool implemented for use either standalone or as part of Kraken database construction, which replaces low-entropy regions with Ns, is presented, demonstrating that it is an effective method for masking low-complexity sequences in large microbial databases, thus improving the accuracy of...

Yu-Chen Ge, Edward Z. Li, Harun Mustafa et al. · 0 citations
Open access Sep 2026

Isocall enables scalable transcript identification from long-read RNA-sequencing data

Isocall, a scalable and deterministic computational method for jointly calling transcripts from multiple PacBio long-read RNA sequencing samples, converts aligned full-length non-concatemer reads into compact per-sample transcript profiles, merges these profiles across samples, and jointly identifies known and novel tr...

E. Dolzhenko, Megan D. Schertzer, Ryan Gossart et al. · 1 citation

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