Calreticulin exposure is a critical mediator of high-dose vitamin C-induced immune surveillance in the tumor microenvironment.
High-dose vitamin C (vitC) has shown superior anticancer activity in immunocompetent compared with immunodeficient mice, suggesting an immunodependent mechanism of action. Because high-dose vitC generates substantial reactive oxygen species (ROS), we hypothesized that ROS could induce immunogenic cell death (ICD), a re...