Alessandro Negri

Phi027 prophage shapes Clostridioides difficile virulence through the SinR/SinR’ axis and the flagellar switch network

Clostridioides difficile is a major nosocomial pathogen whose virulence depends on toxin production and can be shaped by prophage carriage. Here, we dissect the molecular basis of phi027-dependent phenotypic differences between the clinical RT176 strain 500/12 and its prophage-free derivative CKH08. Comparative tr...