Negative Affective States Are Not Detected in Rats Following an Intravenous Self‐Administration Regimen Leading to Incubation of Oxycodone Craving
ABSTRACT In rats, cue‐induced opioid craving intensifies (incubates) during abstinence from opioid self‐administration and then remains high for a prolonged period. The prolonged plateau models persistent vulnerability to cue‐induced craving and relapse in humans recovering from opioid use disorder. However, a very sig...