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Alexa Semonche

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Open access Oct 2026

Combination chemotherapy potentiates 5-aminolevulic acid-mediated photodynamic therapy killing of patient-derived glioma stem-like cells in vitro

Abstract Background 5-aminolevulinic acid photodynamic therapy (5-ALA PDT) is a promising therapy for glioblastoma (GBM). 5-ALA induces tumor-selective accumulation of protoporphyrin IX (PPIX). Photoactivation of PPIX induces reactive oxygen species generation and tumor cell death. Glioma stem-like cells (GSC) are hypo...

Alexa Semonche, T. Slepak, A. Pascoini et al. · 0 citations

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