Alexander De Rosa

The AML-Associated A338V Mutation Rewires GPR183 Signaling through C-Terminal Ensemble Redistribution

G protein–coupled receptors (GPCRs) rely on dynamic conformational ensembles to coordinate G protein activation and recruitment of regulatory transducers such as GPCR kinases and β-arrestins. The oxysterol receptor GPR183 has been implicated in hematological malignancies, including acute myeloid leukemia (AML), where...