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Author

Alexander Harjung

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Open access Aug 2026

Light-Triggered Decoding of Hydrophobic Interactions in Living Systems

The hydrophobic effect is central to biological organization, underlying membrane assembly, molecular recognition, and protein folding. Despite its importance, spatiotemporal control of hydrophobicity is challenging because it emerges from collective solvation free-energy effects around hydrocarbon frameworks whose C...

Peng Ji, Stormi R. Chadwick, Alexander Harjung et al. · 0 citations
Open access Jul 2026

Cryo-EM reveals that Escherichia coli tRNA-transglycosylase can bind and act upon two tRNAs

This work reveals that, unlike all other known TGTs, the E. coli TGT homodimer forms covalent intermediates with two tRNAs, which advance the understanding of TGT enzymology and provide a structural foundation for the development of antibiotics and next-generation RNA-labeling tools.

Alexander Harjung, Ember M Ruth, Mariusz Matyszewski et al. · 0 citations

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