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Author

Alexander J. Powell

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2 papers indexed here

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Aug 2026

Structure-Function Analysis of the Benzyloxy Moiety of the Delta-Opioid Receptor Positive Modulator BMS-986187: Identification of a Derivative with High Selectivity for the Delta-Opioid Receptor over the Mu-Opioid Receptor In Vitro and In Vivo.

A structure-activity study of the benzyloxy moiety of BMS-986187 is reported to improve selectivity for DOR over MOR, while retaining DOR-PAM potency.

Meng-Chu Li, Sherrice Zhang, Alexander J. Powell et al. · 0 citations
Open access Aug 2026

High potency μ-opioid receptor agonists engage sodium-bound receptor states.

The simple 2-state conformational selection model of G protein-coupled receptor activation suggests that, by binding to a high-affinity state, an agonist shifts receptor equilibrium in favor of active state (R∗) conformations that recruit heterotrimeric G proteins over inactive (R) conformations. Agonist binding affini...

Alexander J. Powell, Nicholas W. Griggs, J. Iñiguez-Lluhí et al. · 0 citations

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