Alexander P. Hynes

Trimethoprim suppress phage activity and reduces toxin production in a clinical STEC strain, even in the presence of DNA-damaging antibiotics

Shiga toxin-producing Escherichia coli (STEC) are virulent due to their production of lethal toxins, which are genetically encoded by viruses that exclusively infect these bacteria, called phages. After infection, children and immunocompromised patients are particularly at risk of developing life-threatening complicati...