Author

Alexander R. Dunn

2 papers indexed here

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#machine learning Preprint Oct 2026

Generative modeling of intrinsically disordered protein regions by reinforcing sparse autoencoder features

Intrinsically disordered protein regions (IDRs) play central roles in cellular processes such as transcriptional regulation, signal transduction, and subcellular localization, yet their functional design remains challenging. Structure-based design methods do not readily apply to IDRs, and existing protein language mode...

J. Liu, Sebastian Ibarraran, Frank Hu et al. · 0 citations

Open access Aug 2026

Cryo-Electron Tomography Reveals Nanoscale Thick Filament Disorganization in MYH7 P710R Hypertrophic Cardiomyopathy Cardiomyocytes

Hypertrophic cardiomyopathy (HCM) is the most common monogenic inherited heart disease and is a major cause of sudden death in individuals under 35 years of age. HCM is associated with progressive tissue-level disarray and subcellular disorganization in individual cardiomyocytes. Mutations in β-cardiac myosin (MYH7),...

Magda Zaoralová, Joseph Yoniles, Prerna Giri et al. · ACS Nano · 0 citations