Open access
Sep 2026
No evidence of major integrative brain clearance impairment in an Alzheimer´s disease model of transgenic APPswe/PS1dE9 mice
The findings indicate that the APPswe/PS1dE9 mouse model does not exhibit evidence of major integrative brain clearance impairment, despite this being a hallmark of sporadic AD in humans and suggest limitations of this model for studying clearance-related mechanisms of late-onset AD should be acknowledged when planning...
L. Müller, Charlotte Köhler, T. Lindner et al.
· Fluids and Barriers of the C... · 0 citations