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Alexandra Avramovska

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Open access Jul 2026

Association between initial treatment strategy and progression to difficult-to-treat rheumatoid arthritis (D2T-RA): evidence from a 20-year-old real-world cohort

Abstract Background/objectives Despite major advances in rheumatoid arthritis (RA) management, a substantial proportion of patients evolve to difficult-to-treat RA (D2T-RA). We estimated the probability of progression to D2T-RA and assessed whether the initial choice of biological/targeted synthetic disease-modifying a...

C. Van Mullem, F. Natalucci, Alexandra Avramovska et al. · 0 citations

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