Author

Alexandra M. M. Antunes

2 papers indexed here

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Open access Sep 2026

Covalent Targeting and Thermostabilization of Oncogenic R280K and R273H Mutants p53 by Small Molecule RVJB59

Breast cancer is one of the most common cancers worldwide. Approximately 30%–40% of breast cancers harbor mutations in the TP53 gene, leading to structural and functional alterations in the p53 protein. These changes result in mutant proteins that are unable to perform their canonical tumor suppressor functions and, in...

Ricardo J. F. Ferreira, L. Gonçalves, Mattia Mori et al. · ChemMedChem · 0 citations

Open access Sep 2026

Ni(II) Complexes of 2-Imine-8-Hydroxyquinolines: Characterization, Albumin Binding and Cytotoxicity

Nickel(II) offers an appealing base for metallodrug design as it is abundant, inexpensive and forms well-defined complexes with N,O-donor ligands. Therefore, five Ni(II) complexes containing two tridentate 2-imine-8-hydroxyquinoline Schiff base ligands, derived from morpholine, piperidine, imidazole or 2-methyl-1H-limi...

Sofia Marcão, Leonor Côrte-Real, Alice Alborghetti et al. · Inorganics · 0 citations