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Author

Alexandra Moreno Mitchell

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Open access Sep 2026

Nuclear Myosin VI stabilises Ku-associated DNA ends during nonhomologous end joining

DNA double-strand breaks (DSBs) require rapid signalling and physical stabilisation of broken DNA ends to preserve genome integrity. Here, we identify myosin VI (MVI) as an ATM-regulated component of the DSB response. DNA damage induces rapid nuclear accumulation and nanoscale reorganisation of MVI across multiple cell...

Abdulmohsen Alanazi, Alexander W. Cook, Isabel W. Shahid-Fuente et al. · 0 citations
Review Open access Sep 2026

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma

ABSTRACT Therapeutic strategies for glioblastoma have progressed considerably over recent decades. Despite the development of new biomedical technologies and advances in our understanding of physiology and disease progression, effective drug delivery to brain cancer remains a significant challenge. The challenge is del...

Alexandra R. Paul, Alexandra Moreno Mitchell, Dean O'Neil et al. · 0 citations

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