Alexandre Giusti-Paiva

Endocannabinoid signaling dissociates thermoregulatory and behavioral components of the sickness response to systemic inflammation.

Systemic inflammation triggers a coordinated sickness response that includes behavioral suppression, anorexia, and thermoregulatory alterations, often viewed as a unified syndrome. However, increasing evidence suggests that distinct neural circuits govern different components of sickness behavior. Whether central endoc...