Author

Alexandre Colas

2 papers indexed here

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Sep 2026

Tumor-derived SAA1-TLR4 signaling drives tumor-to-muscle communication in pancreatic cancer cachexia

Conservation of SAA1-TLR4 signaling in human skeletal muscle identifies a therapeutically actionable tumor–host pathway and demonstrates that host deterioration can be targeted independently of tumor progression.

Gabriele Guarnaccia, Jimmy Massenet, Alessandra Cecchini et al. · bioRxiv · 0 citations

Open access Jul 2026

Sulfotransferase signaling sustains fibroblast identity and antagonizes therapeutic cardiac reprogramming

Differentiated cells maintain their identity through active mechanisms that suppress alternative cell fates, but disrupting these barriers can enhance direct reprogramming for organ repair. Among the regulators of cell fate stability, glycosylation-associated genes have emerged as barriers to cardiac reprogramming. Her...

Michaela R. Romero, S. Murphy, Yuzhu Chang et al. · Nature Communications · 0 citations