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Alexandre Vallée

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Open access Aug 2026

From digital twins to clinically trustworthy twins: a clinical-claim-based validation framework for personalized digital health

Digital twins are increasingly presented as a computational foundation for personalized and preventive medicine, because they promise to integrate multimodal data into dynamic representations of patients, organs, diseases, or care pathways. Yet the translational maturity of medical digital twins remains limited. Many s...

Alexandre Vallée · 0 citations
Review Open access Aug 2026

Validating medical digital twins for clinical decision support: beyond predictive accuracy

Intervention-oriented digital twins address action-conditioned questions: what is predicted to happen under specified alternative actions, assumptions, time horizons, and clinical contexts and their validation should extend beyond scalar performance metrics to include uncertainty representation.

Alexandre Vallée · 0 citations

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