Open access
Oct 2026
Modular multifunctional 5HP2O linkers for the versatile assembly of protein-oligonucleotide conjugates
As complex biotherapeutics continue to evolve, the demand for single-site, multi-functionalized protein conjugates intensifies. Current methods often suffer from maleimide-related hydrolytic instability or require multi-step invasive protein modifications. Here, we establish 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones (5H...
Jan H. Meffert, Alexandros Kostakis, Joshua McHale et al.
· Communications Chemistry · 0 citations