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Author

Alexia Ferrand

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Open access Sep 2026

A combinatorial pre-mRNP retention factor network couples nuclear speckle architecture to splicing quality control

Cells must prevent incompletely spliced transcripts from entering the cytoplasm, yet how splicing status is recognized and converted into selective nuclear retention remains unclear. Here, we identify a network of RNA-binding proteins that retain pre-mRNPs within nuclear speckles. Proteomic analysis of splicing interme...

K. Dörner, K. Kurth, Nicole Beuret et al. · 0 citations
Open access Sep 2026

A bacterial nucleolus for cold adaptation

Compartmentalisation enables cells to spatially organise essential biochemical processes. This is exemplified by the eukaryotic nucleolus, which concentrates the machinery for ribosome biogenesis1,2. Bacteria are generally thought to lack an equivalent compartment. Here we discover a nucleolus-like condensate in Escher...

M. Gut, K. Dörner, Sebastian Abegg et al. · 0 citations

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