Therapeutic strategies for downregulating isocitrate dehydrogenase in the treatment of glioblastoma multiforme
IDH-wildtype glioma (Glioblastoma) is the most lethal primary brain tumor in adults, with a median survival of 12–15 months despite optimal treatment. The isocitrate dehydrogenase (IDH) enzyme family, particularly IDH1, plays a central role in Glioblastoma Multiforme (GBM) pathobiology by regulating cellular redox home...